Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B - ReadingSample
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Total synthesis of plakortide E and biomimetic synthesis of plakortone B.
The total synthesis of plakortide E (1a) is reported. A novel palladium-catalyzed approach towards 1,2-dioxolanes as well as an alternative substrate-controlled route leading exclusively to cis-highly substituted 1,2-dioxolanes have been developed. A lipase-catalyzed kinetic resolution was employed to provide optically pure 1,2-dioxolane central cores. Coupling of the central cores and side cha...
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